Synaptic Transmission: Kinetics of synaptic-vesicle recycling

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Synaptic Transmission: Kinetics of synaptic-vesicle recycling

The kinetics of different steps in synaptic-vesicle recycling, including exocytosis, internalization and repriming, have recently been estimated in various types of living cell.

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Synaptic vesicles (SVs) undergo a cycle of biogenesis and membrane fusion to release transmitter, followed by recycling. How exocytosis and endocytosis are coupled is intensively investigated. We describe an all-optical method for identification of neurotransmission genes that can directly distinguish SV recycling factors in C. elegans, by motoneuron photostimulation and muscular RCaMP Ca2+ ima...

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Synaptic Vesicle Recycling: The Ferrari of endocytosis?

After neurotransmission, neurons internalize and recycle the membrane components of synaptic vesicles remarkably quickly; they may have a 'rebuilt, turbo-charged' endocytic engine to achieve these speeds.

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Mutations in Synaptojanin Disrupt Synaptic Vesicle Recycling

Synaptojanin is a polyphosphoinositide phosphatase that is found at synapses and binds to proteins implicated in endocytosis. For these reasons, it has been proposed that synaptojanin is involved in the recycling of synaptic vesicles. Here, we demonstrate that the unc-26 gene encodes the Caenorhabditis elegans ortholog of synaptojanin. unc-26 mutants exhibit defects in vesicle trafficking in se...

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SNARE force synchronizes synaptic vesicle fusion and controls the kinetics of quantal synaptic transmission.

Neuronal communication relies on rapid and discrete intercellular signaling but neither the molecular mechanisms of the exocytotic machinery that define the timing of the action potential-evoked response nor those controlling the kinetics of transmitter release from single synaptic vesicles are known. Here, we investigate how interference with the putative force transduction between the complex...

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ژورنال

عنوان ژورنال: Current Biology

سال: 1995

ISSN: 0960-9822

DOI: 10.1016/s0960-9822(95)00220-x